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Home / All About Herbs / About Grape Seed Extract Monograph


© 2018 Steven Foster

A grape seed monograph for the home

Latin Name: Vitis vinifera

Common Names: grape seed extract, grape seed

This fact sheet provides basic information about grape seed extract—common names, usefulness and safety, and resources for more information.


Grape Seed Basics

  • Since ancient Greece people have used grapes, grape leaves, and sap for health purposes. Grape seed extract was developed in the 1970s.
  • Today, grape seed extract is used as a dietary supplement for various conditions, including for venous insufficiency (when veins have problems sending blood from the legs back to the heart), to promote wound healing, and to reduce inflammation.
  • Grape seed extract contains the antioxidant compound oligomeric proanthocyanidin (OPC), which has been studied for a variety of health conditions.
  • OPCs are found in extracts of grape skin and seeds, which are by-products of the wine industry. Grape seed extract is available in capsules and tablets and as a liquid.

Grape Seed in Health Research

  • There are a few well-controlled studies of people using grape seed extract for health conditions.

Grape Seed Research Summary

  • Some studies suggest that compounds in grape seed extract may reduce edema (swelling) and help with symptoms of chronic venous insufficiency, but the evidence isn’t strong.
  • Grape seed extract may have some heart benefits, including lowering systolic blood pressure and heart rate. The lower heart rate may cause the decrease in systolic blood pressure. The extract had no effect on lipid levels such as cholesterol or C-reactive protein, an indication of inflammation in your arteries.
  • The National Center for Complementary and Integrative Health (NCCIH) is supporting preliminary research on grape seed extract for Alzheimer’s disease and also for hereditary hemochromatosis, when the body’s iron levels are too high. The National Cancer Institute is supporting preliminary studies on grape seed extract for preventing prostate, lung, and colon cancer.

Grape Seed Safety

  • Grape seed extract is generally well tolerated when taken in moderate amounts. It has been tested safely for up to 14 weeks in studies of people. It’s possibly unsafe if you have a bleeding disorder or are going to have surgery or if you take anticoagulants (blood thinners), such as warfarin or aspirin.

Grape Seed References


PubMed Articles About Vitis vinifera

Source: National Center for Biotechnology Information (NCBI)[Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; [1988] – [cited 2018 Apr 5]. Available from:

Pazos-Tomas, CC., Cruz-Venegas, A., Pérez-Santiago, AD., Sánchez-Medina, MA., Matías-Pérez, D., García-Montalvo, IA., (2020) Vitis vinifera: An Alternative for the Prevention of Neurodegenerative Diseases.

To present a systematic review of published studies in databases such as PUBMED, REDALYC, SCIELO, DIALNET, SCOPUS, EBSCO and CONRICYT related to the role-played by the components present in the vegetable oil of grape seed (Vitis vinífera) and the prevention or delay in the onset or progression of neurodegenerative diseases. The analysis of the research revealed that neurodegenerative diseases causes alterations in consciousness or in the nervous system leading to severe damage in neuronal cells, these pathologies are considered gradual and progressive. Various syndromes manifest the degenerative diseases of the nervous system; in some of them the predominant symptom is the progressive dementia. Among the components of the diet that in numerous epidemiological studies have shown an inverse association are vitamins, minerals, carotenoids, polyunsaturated fatty acids and polyphenols, the latter being the ones addressed in this document. There is an important evidence that a nutritional support based on polyunsaturated fatty acids and antioxidants can be applied to subjects with a history of neurodegenerative conditions in order to act as neuroprotectors. This requires the determination of the nutritional benefits of these nutrients or of nutraceuticals for the health of this group of patients.

Mishra, P., Marwah, N., Agarwal, N., Chaturvedi, Y., Suohu, T., (2020) Comparison of , and Seed Extracts used as Mouthrinse on Salivary Levels in Children.

The present study was conducted to compare the efficacy of all , and on salivary levels in children and also to evaluate their substantivity at an interval of 15 days that is at day 1, days 16, and 31.

Parandoosh, M., Yousefi, R., Khorsandi, H., Nikpayam, O., Saidpour, A., Babaei, H., (2020) The effects of grape seed extract (Vitis vinifera) supplement on inflammatory markers, neuropeptide Y, anthropometric measures, and appetite in obese or overweight individuals: A randomized clinical trial.

Grape seed extract (GSE) is a natural supplement known for its various health benefits, including anti-inflammatory effect. This study aimed to evaluate the effects of GSE supplementation on inflammatory markers, neuropeptide Y, anthropometric measurements, and appetite in obese or overweight individuals.

Safaei, N., Babaei, H., Azarfarin, R., Jodati, AR., Yaghoubi, A., Sheikhalizadeh, MA., (2018) Comparative effect of grape seed extract () and ascorbic acid in oxidative stress induced by on-pump coronary artery bypass surgery.

This study aimed to test the beneficial effect of grape seed extract (GSE) (Vitis vinifera) and Vitamin C in oxidative stress and reperfusion injury induced by cardiopulmonary bypass (CPB) in coronary artery bypass surgery.

Rayyan, M., Terkawi, T., Abdo, H., Abdel Azim, D., Khalaf, A., AlKhouli, Z., Meziad, M., Alshamma'a, M., Abu Naim, H., (2018) Efficacy of grape seed extract gel in the treatment of chronic periodontitis: A randomized clinical study.

The aim of the present study was to assess the effectiveness of applying grape seed extract (GSE) gel in periodontal pockets for the treatment of chronic periodontitis.