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thunder god vine

© Frédéric Tournay

A thunder god vine monograph for the home

Latin Name: Tripterygium wilfordii


Common Names: thunder god vine, lei gong teng


This thunder god vine monograph provides basic information about thunder god vine—common names, usefulness and safety, and resources for more information.

Source: https://nccih.nih.gov/

Thunder God Vine Basics

  • Thunder god vine is a perennial grown in China and Taiwan. It has been used for hundreds of years in traditional Chinese medicine to treat swelling caused by inflammation.
  • Currently, thunder god vine is used orally (by mouth) as a dietary supplement for autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and lupus. It is also used topically for rheumatoid arthritis.
  • Extracts are prepared from the roots of thunder god vine.

Thunder God Vine in Health Research

  • A small number of studies have evaluated oral thunder god vine for rheumatoid arthritis. Very little research has been done on thunder god vine for other health conditions or on topical use of this herb for rheumatoid arthritis.

Thunder God Vine Research Summary

  • There have been only a few high-quality studies of oral thunder god vine for rheumatoid arthritis in people. These studies indicate that thunder god vine may improve some rheumatoid arthritis symptoms.
  • Results from a small 2009 study funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), which compared an extract of thunder god vine root with a conventional drug (sulfasalazine) for rheumatoid arthritis, found that participants’ symptoms (e.g., joint pain and swelling, inflammation) improved significantly more with thunder god vine than with the drug.
  • A study from China, published in 2014, compared thunder god vine to a conventional drug (methotrexate) and found that both were comparably helpful in relieving rheumatoid arthritis symptoms, and that the combination of the herb and the drug was better than either one alone.
  • There is not enough evidence to show whether thunder god vine is helpful for any health conditions other than rheumatoid arthritis or whether its topical use in rheumatoid arthritis has any benefits.

Thunder God Vine Safety

  • Thunder god vine may have side effects, including decreased bone mineral content (with long-term use), infertility, menstrual cycle changes, rashes, diarrhea, headache, and hair loss. Because some of these side effects are serious, the risks of using thunder god vine may be greater than its benefits.
  • Thunder god vine can be extremely poisonous if the extract is not prepared properly.

Thunder God Vine References

 

PubMed Articles About


Source: National Center for Biotechnology Information (NCBI)[Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; [1988] – [cited 2018 Apr 5]. Available from: https://www.ncbi.nlm.nih.gov/

Wang, CX., Wu, D., Yang, PP., Wu, QH., (2020) [Efficacy and safety of non-vitamin K antagonist versus vitamin K antagonist oral anticoagulants in the prevention and treatment of thrombotic disease in active cancer patients: a systematic review and meta-analysis of randomized controlled trials].

We aimed to compare the efficacy and safety of non-vitamin K antagonist oral anticoagulants (NOAC) and vitamin K antagonist (VKA) in the prevention and treatment of thrombotic diseases in patients with active cancer. To find randomized controlled trials (RCT) in which NOACs were compared VKAs in active cancer, we searched the electronic databases (PubMed, Web of Science and Clinical Trials) up to May 2019 and and languages restricted to Chinese and English. According to the screening strategy, two researchers independently screened and extracted literature, evaluated the quality of literature, the suitability of collected cross study data for analysis, and tested the heterogeneity. The relative risk () and 95% confidence interval (95%) of major bleeding, clinically related non-major bleeding, VTE, stroke and all-cause mortality in active cancer patients with VTE, active cancer patients with non-valvular atrial fibrillation (NVAF) was calculated and the results were compared between NOAC with VKA. A total of 9 RCTs were included, including 5 cancers with VTE (5/9) and 4 cancers with NVAF (4/9). A total of 5 867 patients were included. After excluding 1 818 (30.99%) patients with cancer history, 4 049 (68.86%) patients with active cancer were statistically analyzed. Among them, 2 278 (56.26%) received NOAC treatment, 1 771 patients (43.74%) received VKA treatment. The quality of the included documents was high (all scores were>5 points), and the data of each included document could be summarized and analyzed (>0.05). The heterogeneity of main outcome events was very low ( = 0). In VTE patients with active cancer, NOACs were more effective in reducing recurrence of VTE (=0.55, 95% 0.36 -0.84; 0.005) and clinically related non-major bleeding (=0.77, 95% 0.60 -0.98; 0.03) than VKAs. In NVAF patients with active cancer, efficacy of NOACs and VKAs was similar in terms of reducing VTE, stroke, clinically related non-major bleeding, major bleeding and all-cause mortality events (>0.05). For patients with active cancer accompanied by VTE, NOAC may has more advantages in efficacy and safety compared to VKA in the prevention and treatment of thrombotic diseases.

Zhang, ZD., Liu, H., Lyu, J., Yu, DD., Sun, MH., (2020) [Systematic review and Meta-analysis of efficacy and safety of Xiangsha Yangwei Pills in treatment of chronic gastritis].

To systematically evaluate the efficacy and safety of Xiangsha Yangwei Pills in the treatment of chronic gastritis. Compu-ter retrieval was performed for Cochrane Library, Medline, EMbase, China Knowledge Network Database(CNKI), China Biomedical Literature Service System(SinoMed), Chongqing Weipu Chinese Science and Technology Journal Database(VIP) and WanFang Database(WanFang) randomized controlled trials about Xiangsha Yangwei Pills combined with Western medicine in the treatment of chro-nic gastritis. The retrieval time ranged from the establishment of the library to April 26, 2019. Meta-analysis was performed by RevMan 5.3 software after two independent researchers conducted literature screening, data extraction and quality evaluation according to inclusion and exclusion criteria. A total of 1 720 patients were enrolled in 18 RCT. According to the classification of chronic gastritis, they were divided into three subgroups: chronic gastritis, chronic atrophic gastritis and chronic superficial gastritis. The results of Meta-ana-lysis showed that the efficacy of Xiangsha Yangwei Pills combined with Western medicine in treating chronic gastritis was higher than that of Western medicine. As for the recurrence rate, Xiangsha Yangwei Pills combined with Western medicine was lower than Western medicine. And there was no statistical difference about helicobacter pylori(Hp) eradication rate between Xiangsha Yangwei Pills combined with Western medicine as well as Western medicine. In terms of the incidence of adverse reactions, Xiangsha Yangwei Pills combined with Western medicine was lower than Western medicine, and no serious adverse reaction was reported. The results of this systematic review showed that compared with the conventional Western medicine group, Xiangsha Yangwei Pills combined with Western medicine can significantly alleviate clinical symptoms of chronic gastritis, with fewer adverse reactions. However, due to the low methodological quality of the included studies and the reliability of the impact conclusions, high-quality multi-center, large-sample, randomized, double-blind controlled trials are needed for validation.

Clifford, T., Jeffries, O., Stevenson, EJ., Davies, KAB., (2020) The effects of vitamin C and E on exercise-induced physiological adaptations: a systematic review and Meta-analysis of randomized controlled trials.

We conducted a systematic review and meta-analysis of randomized controlled trials examining the effect of vitamin C and/or E on exercise-induced training adaptations. Medline, Embase and SPORTDiscus databases were searched for articles from inception until June 2019. Inclusion criteria was studies in adult humans where vitamin C and/or E had to be consumed alongside a supervised exercise training program of ≥4 weeks. Nine trials were included in the analysis of aerobic exercise adaptations and nine for resistance training (RT) adaptations. Vitamin C and/or E did not attenuate aerobic exercise induced improvements in maximal aerobic capacity (O (SMD -0.14, 95% CI: -0.43 to 0.15,  = 0.35) or endurance performance (SMD -0.01, 95% CI: -0.38 to 0.36,  = 0.97). There were also no effects of these supplements on lean mass and muscle strength following RT (SMD -0.07, 95% CI: -0.36 to 0.23,  = 0.67) and (SMD -0.15, 95% CI: -0.16 to 0.46,  = 0.35), respectively. There was also no influence of age on any of these outcomes ( > 0.05). These findings suggest that vitamin C and/or E does not inhibit exercise-induced changes in physiological function. Studies with larger sample sizes and adequate power are still required.

Chen, G., Chen, Y., Chen, Z., Gao, S., Zhang, P., Zhang, H., Huang, Y., Lin, Y., Wei, L., (2021) Sanao decoction for asthma: Protocol of a systematic review.

Asthma is a chronic inflammatory disease characterized by recurrent attacks of breathlessness and wheezing, which often worsen at night or in the early morning and vary from person to person in severity and frequency. Sanao decoction (SAD), as a traditional Chinese medicine compound, has a long history of clinical application in the treatment of respiratory diseases. Whereas neither systematic nor meta-analysis of randomized controlled articles explain the efficacy of SAD in treating asthma. Therefore, we provide a protocol to evaluate the efficacy and safety of SAD for asthma.